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Image Search Results
Journal: Epigenomics
Article Title: Trans-acting epigenetic effects of chromosomal aneuploidies: lessons from Down syndrome and mouse models
doi: 10.2217/epi-2016-0138
Figure Lengend Snippet: Diagram of chromosome 21 (Hsa21), which is trisomic in Down syndrome. Effector genes on the triplicated Hsa21 act on downstream target genes, mostly on other chromosomes, both by acute transcriptional effects and via epigenetic effects, including alterations in DNA methylation that can propagate to daughter cells in growing and self-renewing tissues, to produce biological phenotypes. DS-DM: Differential CpG methylation.
Article Snippet: Microarray-based
Techniques: DNA Methylation Assay, CpG Methylation Assay